Graft rejection is a critical challenge in organ transplantation, occurring when a recipient's immune system identifies the transplanted organ as foreign and...
Graft rejection is a process where the recipient's immune system recognizes a transplanted organ or tissue as foreign and launches an attack against it, potentially leading to transplant failure.
The main types include hyperacute (immediate), acute (occurring days to months post-transplant), and chronic (long-term, progressive damage) rejection.
Prevention involves tissue matching and lifelong immunosuppressive medications. Management often includes adjusting immunosuppressant doses, administering steroid therapy, or other immune-modulating treatments.
Symptoms vary by organ but can include fever, pain or swelling at the transplant site, fatigue, and signs of organ dysfunction, such as elevated liver enzymes or kidney function markers.