Medscape, a leading medical news source, published its 'Top 10 Obesity Stories of 2025 That Resonated With Readers' on December 29, 2025. This comprehensive review highlighted significant advancements and discussions in obesity research and management throughout the year. Among the key findings and trends featured, one prominent story addressed the real-world efficacy of GLP-1 receptor agonists, such as semaglutide and tirzepatide, noting that actual weight loss results often differed from those observed in clinical trials, with drug costs being a major reason for discontinuation. The article also explored the impact of eating behaviors, including a study suggesting that slowing down and chewing food more thoroughly could aid in reducing food intake and preventing obesity. Dietary chronotype, where meal timing is adapted to an individual's metabolic peaks, was presented as a promising approach for boosting weight loss and gut health. Furthermore, research into the benefits of walnuts demonstrated their potential to improve insulin response and reduce gut permeability in individuals with obesity. The review also touched upon a significant development from January 2025: The Lancet Diabetes and Endocrinology Commission's overhaul of the definition of obesity into clinical and preclinical designations, emphasizing excess adiposity and its multifaceted causes. This Medscape feature, authored by award-winning medical journalist Marilynn Larkin, provides valuable insights into the evolving landscape of obesity treatment and understanding, a topic of critical global and national health importance, including for audiences in India.