Professor Yamuna Krishnan, an accomplished Indian biologist and alumnus of IISc Bangalore, has spearheaded a groundbreaking scientific endeavor by developing ultra-small DNA nanodevices that can function effectively inside living human cells. This innovative approach utilizes DNA-based nanotechnology to reveal the intricate, often hidden, machinery within these microscopic structures. The research aims to shed light on fundamental biological processes occurring within cellular compartments, known as organelles, about which scientists still possess limited understanding. The deployment of these programmable DNA nanodevices offers an unprecedented ability to 'peer into this invisible world' of cellular activity. While modern medicine has made substantial strides in comprehending organs and tissues, the inner workings of individual cells and their organelles remain a complex frontier. This advancement represents a significant leap in the field of cell biology, providing novel tools for deeper investigation into how cells live and operate. DNA nanotechnology, a field that uses nucleic acids as structural engineering materials rather than just genetic carriers, has been evolving for decades, with applications ranging from biosensing and bioimaging to drug delivery. Professor Krishnan's work builds upon this foundation, creating functional nanomachines that can interact with the cellular environment. Her prior research includes developing DNA nano-machines to measure cell acidity from the inside, highlighting a consistent focus on intracellular sensing and diagnostics. This latest development promises to unlock new insights into cellular mechanisms, potentially impacting future disease understanding and therapeutic strategies. The discovery underscores India's growing contributions to cutting-edge global scientific research.