US Flu Surges: New H3N2 Subclade K Variant Drives Rapid Rise | Quick Digest
The United States is experiencing a rapid surge in flu cases for the 2025-2026 season, primarily driven by a new H3N2 subclade K variant. Health officials report high activity across over half of US states, with cases, hospitalizations, and deaths significantly increasing. Current vaccines offer partial protection against this emergent strain.
US flu cases are rapidly increasing in the current 2025-2026 season.
A new H3N2 subclade K variant is driving the current flu surge.
CDC reports high or very high flu activity in over half of US states.
Subclade K emerged in the Southern Hemisphere, now spreading globally.
Current flu vaccine provides partial protection against the new subclade K.
H3N2 strains historically lead to more severe flu seasons overall.
The United States is currently experiencing a rapid increase in influenza activity for the 2025-2026 flu season, a development corroborated by the Los Angeles Times and supported by data from leading health organizations. This surge is largely propelled by a newly identified H3N2 influenza A virus variant, known as "subclade K". The Centers for Disease Control and Prevention (CDC) has reported that flu activity has reached high or very high levels in more than half of U.S. states, with millions of illnesses, tens of thousands of hospitalizations, and thousands of deaths already recorded this season.
Subclade K, which was first identified by the CDC in August 2025, is a mutated version of the H3N2 strain, historically linked to more severe flu seasons, particularly affecting older adults. This variant first caused early outbreaks in the United Kingdom, Japan, and Canada before spreading extensively across the U.S.. The World Health Organization (WHO) has also indicated a global rise in influenza activity since October 2025, with A(H3N2) viruses predominating and growing detections of subclade K in North America.
As of late December 2025, CDC estimates showed at least 7.5 million flu illnesses, 81,000 hospitalizations, and 3,100 deaths nationwide, including eight pediatric fatalities. States like New York have reported their highest single-week flu case totals since 2004. While this season's flu vaccine was developed prior to subclade K's full emergence, preliminary analyses from the UK suggest it still offers at least partial protection, effectively reducing the risk of severe illness and hospitalization. Health experts continue to strongly recommend vaccination, emphasizing its role in mitigating severe outcomes.
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