The World Health Organization's (WHO) South-East Asia Region is celebrating a monumental achievement, marking 15 years since the last case of wild poliovirus was detected within its borders. The historic last case was reported on January 13, 2011, in an 18-month-old girl from Howrah, West Bengal, India. This landmark success paved the way for the entire region to be certified wild poliovirus-free on March 27, 2014, following three years without any new cases. This enduring polio-free status, maintained by a region home to a quarter of the world's population, is a testament to unparalleled efforts from governments, dedicated health workers, and strong partnerships, including community engagement. India, once considered the most challenging country for polio eradication, played a crucial role in this regional triumph. The extensive and intensive response following the last reported case ensured that it remained an isolated incident. The legacy of the polio eradication program extends beyond just eliminating the virus. It has significantly contributed to broader public health gains by strengthening routine immunization systems, enhancing public health laboratory capacities, improving disease surveillance networks, and bolstering emergency preparedness across the member states. Countries in the region, including Bangladesh, Bhutan, Democratic People's Republic of Korea, India, Maldives, Myanmar, Nepal, Sri Lanka, Thailand, and Timor-Leste, continue to maintain strict vigilance against poliovirus importation and protect children through consistent vaccination efforts. The success demonstrates that ambitious public health goals are achievable through unwavering commitment and collaborative strategies.