India is marking a significant public health milestone, celebrating 15 years since its last reported case of wild poliovirus. The final case was recorded on January 13, 2011, in Howrah, West Bengal, a date that effectively marked the end of indigenous wild polio transmission in the entire WHO South-East Asia Region. This achievement is particularly noteworthy given that in 2009, India alone accounted for a staggering 60% of the global polio burden, with 741 reported cases. Through an unprecedented mobilization of resources and a concerted national effort, the country managed to report zero cases within two years. The intensive 'Pulse Polio Immunization Programme,' launched in 1995, played a crucial role, involving millions of health workers and volunteers who delivered billions of oral polio vaccine doses to children across the nation. Despite immense challenges such as a large population, poor sanitation, and remote communities, this sustained commitment led to the World Health Organization (WHO) certifying the entire South-East Asia Region as polio-free on March 27, 2014. This success has been hailed globally as a testament to unwavering government leadership, a dedicated health workforce, strong partnerships, and active community participation. India's journey from a polio hotspot to a global leader in immunization offers a critical blueprint for the ongoing worldwide effort to eradicate polio, which remains endemic in only two countries: Pakistan and Afghanistan. To maintain its polio-free status, India continues to implement robust surveillance, conduct regular National and Sub-National Immunization Days, and ensure high vaccination coverage, including the introduction of the Inactivated Polio Vaccine (IPV) into its routine immunization program. This enduring vigilance underscores the importance of continued efforts to protect every child from this preventable disease.