Disrupted Body Clocks Linked to Higher Alzheimer's and Dementia Risk | Quick Digest

Disrupted Body Clocks Linked to Higher Alzheimer's and Dementia Risk | Quick Digest
A recent study suggests that weaker and irregular circadian rhythms, or 'body clocks,' are associated with a significantly increased risk of developing Alzheimer's disease and other forms of dementia. This research highlights the potential role of sleep-wake patterns in long-term brain health and disease progression.

Weaker circadian rhythms significantly increase dementia risk.

Later daily activity peaks linked to 45% higher dementia risk.

Study involved over 2,100 older adults tracked for three years.

Disruptions may impact inflammation and amyloid plaque clearance.

Maintaining regular sleep cycles may be crucial for brain health.

Research published in Neurology, a credible medical journal.

Recent research indicates a significant association between disrupted circadian rhythms, often referred to as the body's internal clock, and an increased risk of developing Alzheimer's disease and other forms of dementia. A study published in *Neurology*, the medical journal of the American Academy of Neurology, found that individuals with weaker and more irregular daily activity patterns were nearly two-and-a-half times more likely to develop dementia. The research also revealed that people whose daily activity levels peaked later in the afternoon (after 2:15 p.m.) faced a 45% higher risk of dementia compared to those with earlier activity peaks. The study involved over 2,100 older adults, with an average age of 79, none of whom had dementia at the outset. Participants wore small monitors for approximately 12 days to track their rest and activity patterns, and researchers then followed them for three years, during which 176 individuals were diagnosed with dementia. Researchers suggest that disruptions in circadian rhythms may affect crucial bodily processes such as inflammation, interfere with sleep quality, potentially increase the buildup of amyloid plaques in the brain (a hallmark of Alzheimer's), or reduce the brain's ability to clear these toxic proteins. While the study highlights an association and does not prove causation, it builds upon earlier research suggesting a link between sleep disturbances and Alzheimer's pathophysiology. Experts emphasize that maintaining a regular sleep schedule, consistent exercise routines, and adequate natural light exposure, especially in the mornings, could be non-invasive ways to help maintain healthy circadian rhythms. These findings underscore the importance of our body clocks in maintaining long-term brain health and open avenues for future research into potential interventions, such as light therapy or lifestyle modifications, to mitigate dementia risk.
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