Enzyme 'Fat Switch' Discovery Shows Promise Against Obesity in Animal Models

Cleveland researchers have identified a novel enzyme, SCoR2, acting as a 'fat switch' that regulates fat synthesis. Blocking this enzyme in mouse models prevented weight gain, lowered bad cholesterol, and reduced liver issues, offering a promising new therapeutic target.

• Cleveland researchers identified a novel enzyme, SCoR2, as a 'fat switch'.
• SCoR2 removes nitric oxide, activating fat synthesis in the body.
• Blocking SCoR2 genetically and pharmacologically prevented weight gain in mice.
• The intervention also lowered 'bad' cholesterol and reduced liver injury in animal models.
• The study was published in the journal Science Signaling on December 23, 2025.
• Human clinical trials for a drug targeting SCoR2 are anticipated in about 18 months.

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