DNA Linker Spacing Controls Chromatin's Fluid-to-Solid State Transition

New research reveals that subtle changes in DNA linker length, as few as five DNA letters, can dynamically switch chromatin between fluid and solid-like states, profoundly impacting gene accessibility and genome organization in cells.

• Minimal DNA sequence changes alter chromatin's physical state.
• Five DNA letters in linker DNA region critical for state flip.
• Discovery fundamentally impacts understanding of gene regulation.
• Chromatin's fluid-to-solid shift influences gene accessibility.
• Study published in the prestigious journal Science.
• Research led by UT Southwestern Medical Centre scientists.

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