Early Pancreatic Cancer Recurrence: Unmasking Biological R2 Enigma

A new article discusses very early recurrence (VER) after pancreatic cancer surgery, termed "biological R2 resection." This phenomenon, where recurrence occurs within 12 weeks, significantly increases mortality, highlighting the urgent need for updated prognostic approaches and risk-stratified patient management.

• Very early recurrence (VER) of pancreatic cancer profoundly impacts patient survival.
• VER, also known as 'biological R2 resection,' is recurrence within 12 weeks post-surgery.
• G3 tumors and pancreatic head location are identified as key predictors for VER.
• Patients with VER face double the 6-month mortality rate compared to others.
• The research advocates for risk-stratified management and intensified postoperative surveillance.
• The study emphasizes the need for further research into molecular drivers of VER.

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