Stiffer Colon Linked to Increased Early-Onset Colorectal Cancer Risk

New research suggests increased colon stiffness, often due to chronic inflammation, may elevate the risk and progression of early-onset colorectal cancer (CRC). This discovery could lead to novel diagnostic tools and treatments for younger patients.

• Increased colon stiffness linked to early-onset colorectal cancer development.
• Chronic inflammation may cause colon stiffening and promote cancer growth.
• Study found denser, more aligned collagen in early-onset CRC samples.
• Cancer cells grow faster on stiffer surfaces, influencing mechanotransduction.
• Findings could enable new diagnostic tests and targeted therapies.
• Early-onset CRC incidence is significantly rising globally.

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